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KMID : 0606920090170010043
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Biomolecules & Therapeutics
2009 Volume.17 No. 1 p.43 ~ p.46
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Inhibition of T-cell-Dependent Antibody Production by Quercetin in Mice
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Kim Hyun-Pyo
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Abstract
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The immunosuppressive properties of flavonoids were examined for the first time by testing their effects on T-cell-mediated antibody production, using a classical plague-forming cell (PFC) assay in mice. Among the tested flavonoids including naringenin, chrysin, flavonol, galangin, quercetin, morin, myricetin and biochanin A, only quercetin, orally administered at 25 mg/kg, significantly inhibited the number of IgMproducing PFCs induced by sheep red blood cells (SRBC). Interestingly, biochanin A (isoflavone) increased the number of PFCs, suggesting an immunostimulatory effect. The other flavonoids tested did not inhibit or enhance PFC response significantly. Quercetin was also found to show thymus atrophy dose-dependently at 5-500 mg/kg. All these results indicate that quercetin inhibits in vivo antibody production probably by inhibiting T-cell function.
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KEYWORD
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Flavonoid, Quercetin, Immunosuppression, Plague-forming cell assay
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